Publications

When Can Weekly Anti-Obesity Peptides Be Used For Monthly Administration? - Diabetes Obes Metab

PET Imaging Using 89Zr-Labeled StarPEG Nanocarriers Reveals Heterogenous Enhanced Permeability and Retention in Prostate Cancer. - Mol Cancer Thera

Intravitreal Injection of Dorzolamide-Loaded Polyethylene Glycol Microsphere Produces  Sustained Lowering of Intraocular Pressure in Rabbits. - Invest. Ophthalmol. Vis. Sci.

The Limitation of Lipidation: Conversion of Semaglutide From Once-Weekly to Once-Monthly Dosing. - PNAS

Leveraging Long-Acting IL-15 Agonists for Intratumoral Delivery and Enhanced Antimetastatic Activity. - Front Immunol

PLX 038A, a Long-Acting SN-38, Penetrates The Blood-Tumor-Brain-Barrier, Accumulates and Releases SN-38 In Brain Tumors To Increase Survival Of Tumor Bearing Mice. - Sci Reports

Synergistic Antitumor Activity of Talazoparib and Temozolomide in Malignant Rhabdoid Tumors. - Cancers

A Platform Technology for Ultra-Long Acting Intratumoral Therapy. - Sci Reports

Long-Acting Poly(ADP-ribose) Polymerase Inhibitor Prodrug for Humans. - Bioconjugate Chem

Could a Long-Acting Prodrug of SN-38 be Efficacious in Sacituzumab Govitecan-Resistant Tumors? - BioDrugs

Improving clinical trial access for people with rare CNS tumors: a phase I/II trial of PLX038 in tumors with MYC-C or MYC-N amplifications incorporating correlative studies and patient reported outcomes (PRO) - An NCI-CONNECT Clinical Trial. - 27th Annual Meeting and Education Day of the Society for Neuro-Oncology

Prostate-Specific Membrane Antigen Targeted Deep Tumor Penetration of Polymer Nanocarriers. - Appl Mater Interfaces

PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma. - iScience

PLX038: A Long-Acting Topoisomerase 1 Inhibitor With Robust Antitumor Activity in ATM-Deficient Tumors and Potent Synergy With PARP Inhibitors. - Mol Cancer Thera

A long-acting C-natriuretic peptide for achondroplasia. - PNAS

Attenuation of the Reaction of Michael Acceptors with Biologically Important Nucleophiles. - Bioconjugate Chem.

Does sacituzumab-govitecan act as a conventional antibody drug conjugate (ADC), a prodrug of SN-38 or both? - Annals of Translational Medicine

Facile preparation of tetra-polyethylene glycol hydrogel microspheres for drug delivery by cross-flow membrane emulsification. - Engineering Reports

Interleukin 15 Pharmacokinetics and Consumption by a Dynamic Cytokine Sink. - Frontiers in Immunology

High-throughput, aseptic production of injectable Tetra-PEG hydrogel microspheres for delivery of releasable covalently bound drugs + SI. - Engineering Reports

Prospective use of the single-mouse experimental design for the evaluation of PLX038A. - Cancer Chemotherapy and Pharmacology

Autoclave sterilization of tetra-polyethylene glycol hydrogel biomaterials with b-elimination crosslinks. - Engineering Reports

PET imaging of the EPR effect in tumor xenografts using small 15 nm diameter polyethylene glycols labeled with zirconium-89. - Molecular Cancer Therapeutics

PLX038: a PEGylated prodrug of SN-38 independence of UGT1A1 activity. - Cancer Chemotherapy and Pharmacology

Species-specific optimization of PEG~SN~38 prodrug pharmacokinetics and antitumor effects in triple-negative BRCA1-deficient xenograft. - Cancer Chemotherapy and Pharmacology

PLX038: A long-acting prodrug of SN-38 and enhancer of the DNA Damage Response. - Gordon Conference

A Controlled Release System for Long-Acting Intravitreal Delivery of Small Molecules. - TVST

Approach For Half-Life Extension of Small Antibody Fragments That Does Not Affect Tissue Uptake. - Bioconjugate Chemistry

Surgical Sealants with Tunable Swelling, Burst Pressures, and Biodegradation Rates. - Journal of Biomedical Materials Research B

Probing the Luminal Microenvironment of Reconstituted Epithelial Microtissues. - Scientific Reports

Subcutaneously Administered Self-Cleaving Hydrogel-Octreotide Conjugated Provide Very Long-Acting Octreotide. - Bioconjugate Chemistry

Analytical and Simulation-Based Models for Drug Release and Gel-Degradation in a Tetra-PEG Hydrogel Drug-Delivery System. - Macromolecules

Half-Life Extension of the HIV-Fusion Inhibitor Peptide TRI-1144 Using a Novel Linker Technology. - European Journal of Pharmaceuticals and Biopharmaceutics

Biodegradable Tetra-PEG Hydrogels as Carriers for a Releasable Drug Delivery System. - Bioconjugate Chem

The Intravitreal Pharmacokinetics of Fluorophores Conjugated to PEGs by Non-Cleavable and Self-Cleaving Linkers in Non-human Primates. - ARVO 2014 Annual Meeting

Beta-Eliminative Releasable Linkers Adapted for Bioconjugation of Macromolecules to Phenols. - Bioconjugate Chem

An optimized hydrogel offers tunable half-life extension of peptides and proteins. - Peptide Conference

Self-administered long-acting octreotide conjugates. - Peptide Conference

Predictable half-life extension demonstrated through peptide TRI-1144. - Peptide Conference